Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 5/20 | 0.54 |
| ▸ | MME | P08473 | 2/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | ECE1 | P42892 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 5/20 | 0.50 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2099399 | 1.00 | NPSR1 (0.56) | NPSR1ACEMMEACE2PTPN1 | |
| SCHEMBL8613833 | 0.88 | NPSR1 (0.69) | NPSR1ACEMMEACE2ECE1 | |
| SCHEMBL5180354 | 0.88 | NPSR1 (0.69) | NPSR1ACEMMEACE2ECE1 | |
| SCHEMBL5180357 | 0.88 | NPSR1 (0.69) | NPSR1ACEMMEACE2ECE1 | |
| SCHEMBL908205 | 0.82 | ACE (0.63) | NPSR1ACEMMEACE2ECE1 | |
| SCHEMBL11459401 | 0.82 | ACE (0.63) | NPSR1ACEMMEACE2CA2 | |
| SCHEMBL8726475 | 0.82 | ACE (0.63) | NPSR1ACEMMEACE2ECE1 | |
| SCHEMBL908204 | 0.82 | ACE (0.63) | NPSR1ACEMMEACE2ECE1 | |
| SCHEMBL11459400 | 0.82 | ACE (0.63) | NPSR1ACEMMEACE2CA2 | |
| SCHEMBL10626666 | 0.81 | LMNA (0.56) | ACEMMEACE2PTPN1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440988-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440988-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-09-13 | — | — | US | disclosed |
| US-20120135066-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | BEACHY PHILIP A (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120135066-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | BEACHY PHILIP A (US) | 2012-05-31 | — | — | US | disclosed |
| US-8163719-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163719-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-04-24 | — | — | US | disclosed |
| US-20110263519-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263519-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-10-27 | — | — | US | disclosed |
| US-7998946-B2 | Veratrum-type alkaloid inhibits mitotic cell proliferation in hedgehog-mediated signal transduction with an ED50 of 1 mM or less; preparations administered systemically, locally, topically; cancer; non-malignant hyperproliferative disorders | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998946-B2 | Veratrum-type alkaloid inhibits mitotic cell proliferation in hedgehog-mediated signal transduction with an ED50 of 1 mM or less; preparations administered systemically, locally, topically; cancer; non-malignant hyperproliferative disorders | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-08-16 | — | — | US | disclosed |
| US-7476661-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080255059-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-10-16 | — | — | US | disclosed |
| US-20080255059-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-10-16 | — | — | US | disclosed |
| EP-1728797-A2 | Regulators of the hedgehog pathway, compositions and uses related thereto | Johns Hopkins University School of Medicine (US) | 2006-12-06 | — | — | EP | disclosed |
| US-7098196-B1 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-08-29 | — | — | US | disclosed |
| US-20060128639-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-15 | — | — | US | disclosed |
| EP-1235851-B1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | UNIV JOHNS HOPKINS MED (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1235851-A2 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | Johns Hopkins University School of Medicine (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001027135-A9 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | UNIV JOHNS HOPKINS MED (US) | 2002-08-15 | — | — | WO | disclosed |
| WO-2001027135-A2 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255059-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | SHH, GLI1, SMO | NPSR1 4650/4885ACE 4863/4885MME 4412/4885 |
| US-20120135066-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | NPSR1 4650/4885ACE 4863/4885MME 4412/4885 |
| US-20110263519-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | NPSR1 4650/4885ACE 4863/4885MME 4412/4885 |
| US-20060128639-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | SHH, GLI1, SMO | NPSR1 4650/4885ACE 4863/4885MME 4412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.