Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | GRN | P28799 | 2/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 8/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20994241 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL15144998 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL19083953 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL20994308 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL20994304 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL20994281 | 0.83 | GRN (0.52) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL20994283 | 0.83 | GRN (0.52) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL7843875 | 0.81 | GRN (0.55) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL29511128 | 0.81 | GRN (0.55) | SMN1; SMN2BLMKDM4EMAPTTHRB | |
| SCHEMBL6467188 | 0.81 | GRN (0.55) | SMN1; SMN2BLMKDM4EMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563074-B | Piperazine derivatives | 安斯泰来制药株式会社 | 2021-09-28 | — | — | CN | disclosed |
| EP-3489231-B1 | PIPERAZINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2021-06-09 | — | — | EP | disclosed |
| US-10710988-B2 | Piperazine derivative | ASTELLAS PHARMA INC. (JP) | 2020-07-14 | — | — | US | disclosed |
| US-20190202815-A1 | PIPERAZINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2019-07-04 | — | — | US | disclosed |
| EP-3489231-A1 | PIPERAZINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2019-05-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10710988-B2 | Piperazine derivative | GPR4, MC4R, TRPC4 | SMN1; SMN2 2030/4885BLM 4006/4885KDM4E 1465/4885 |
| US-20190202815-A1 | PIPERAZINE DERIVATIVE | GPR4, MC4R, TRPC4 | SMN1; SMN2 2030/4885BLM 4006/4885KDM4E 1465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.