Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 2/20 | 0.33 |
| ▸ | CA5A | P35218 | 2/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8140158 | 0.94 | ALDH1A1 (0.33) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6129080 | 0.86 | ALDH1A1 (0.42) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27324540 | 0.84 | MGLL (0.30) | — | |
| SCHEMBL18395911 | 0.83 | PREP (0.35) | POLB | |
| SCHEMBL7699524 | 0.83 | SMN1; SMN2 (0.47) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL16418492 | 0.83 | — | — | |
| SCHEMBL888243 | 0.81 | MEN1 (0.51) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2100045 | 0.81 | MEN1 (0.51) | ALDH1A1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4204236 | 0.81 | PSMB8 (0.32) | ALDH1A1 | |
| SCHEMBL12568580 | 0.81 | RECQL (0.33) | ALDH1A1SMN1; SMN2HPGDRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440988-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-09-13 | — | — | US | disclosed |
| US-9440988-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-09-13 | — | — | US | disclosed |
| US-20120135066-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | BEACHY PHILIP A (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120135066-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | BEACHY PHILIP A (US) | 2012-05-31 | — | — | US | disclosed |
| US-8163719-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163719-B2 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-04-24 | — | — | US | disclosed |
| US-20110263519-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263519-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-10-27 | — | — | US | disclosed |
| US-7998946-B2 | Veratrum-type alkaloid inhibits mitotic cell proliferation in hedgehog-mediated signal transduction with an ED50 of 1 mM or less; preparations administered systemically, locally, topically; cancer; non-malignant hyperproliferative disorders | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998946-B2 | Veratrum-type alkaloid inhibits mitotic cell proliferation in hedgehog-mediated signal transduction with an ED50 of 1 mM or less; preparations administered systemically, locally, topically; cancer; non-malignant hyperproliferative disorders | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2011-08-16 | — | — | US | disclosed |
| US-20080255059-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-10-16 | — | — | US | disclosed |
| US-20080255059-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-10-16 | — | — | US | disclosed |
| US-20080255059-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-10-16 | — | — | US | disclosed |
| EP-1728797-A2 | Regulators of the hedgehog pathway, compositions and uses related thereto | Johns Hopkins University School of Medicine (US) | 2006-12-06 | — | — | EP | disclosed |
| US-7098196-B1 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-08-29 | — | — | US | disclosed |
| US-20060128639-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-15 | — | — | US | disclosed |
| EP-1235851-B1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | UNIV JOHNS HOPKINS MED (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1235851-A2 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | Johns Hopkins University School of Medicine (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001027135-A9 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | UNIV JOHNS HOPKINS MED (US) | 2002-08-15 | — | — | WO | disclosed |
| WO-2001027135-A2 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255059-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | SHH, GLI1, SMO | ALDH1A1 3430/4885POLB 3067/4885SMN1; SMN2 3651/4885 |
| US-20120135066-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | ALDH1A1 3430/4885POLB 3067/4885SMN1; SMN2 3651/4885 |
| US-20110263519-A1 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | ALDH1A1 3430/4885POLB 3067/4885SMN1; SMN2 3651/4885 |
| US-20060128639-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | SHH, GLI1, SMO | ALDH1A1 3430/4885POLB 3067/4885SMN1; SMN2 3651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.