Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2102483 | 0.91 | ABCB11 (0.57) | ABCB11CNR2GSTO1GAACNR1 | |
| SCHEMBL2099210 | 0.84 | CNR2 (0.46) | ABCB11CNR2GSTO1GAACNR1 | |
| SCHEMBL3838582 | 0.82 | CNR2 (0.47) | CNR2GSTO1GAACNR1SMN1; SMN2 | |
| SCHEMBL2099477 | 0.81 | CNR2 (0.46) | CNR2GSTO1GAACNR1SMN1; SMN2 | |
| SCHEMBL2100338 | 0.80 | PTGDR2 (0.50) | CNR2GSTO1TP53MAPTPKM | |
| SCHEMBL2101692 | 0.78 | CNR2 (0.49) | CNR2GSTO1GAACNR1SMN1; SMN2 | |
| SCHEMBL2100681 | 0.77 | ABCB11 (0.47) | ABCB11GAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2101132 | 0.76 | ABCB11 (0.64) | ABCB11CNR2GAAALDH1A1KDM4E | |
| SCHEMBL1753809 | 0.74 | MEN1 (0.56) | GAACNR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2100236 | 0.74 | ABCB11 (0.79) | ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163727-B2 | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |