Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25514792 | 0.85 | CCNE1 (0.41) | ALDH1A1KDM4EGAAMAPTHTT | |
| SCHEMBL19663382 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDHSD17B10MIF | |
| SCHEMBL26011534 | 0.82 | KMT2A (0.39) | HPGDMIFGAAMAPTMEN1 | |
| SCHEMBL14434944 | 0.81 | CYP19A1 (0.42) | ALDH1A1KDM4EHSD17B10MAPTL3MBTL1 | |
| SCHEMBL17324236 | 0.80 | CYP19A1 (0.38) | MIFMEN1KMT2ACYP19A1HDAC1 | |
| SCHEMBL26225463 | 0.79 | CCNE1 (0.34) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL21152290 | 0.78 | CYP19A1 (0.39) | MIFMEN1KMT2ACYP19A1HDAC1 | |
| SCHEMBL24618012 | 0.77 | NR2F2 (0.41) | HPGDMAPTMEN1KMT2ARAB9A | |
| SCHEMBL22170194 | 0.76 | FOLH1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10HDAC1 | |
| SCHEMBL23771990 | 0.74 | ALB (0.41) | MAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11241502-B2 | Stable compositions of pegylated carfilzomib compounds | AMGEN INC. (US) | 2022-02-08 | — | — | US | disclosed |
| US-20190142957-A1 | STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS | AMGEN INC. | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190142957-A1 | STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS | MCL1, PHOSPHO1, PSMB5 | ALDH1A1 4129/4885KDM4E 850/4885HPGD 3351/4885 |
| US-11241502-B2 | Stable compositions of pegylated carfilzomib compounds | MCL1, PHOSPHO1, PSMB5 | ALDH1A1 4129/4885KDM4E 850/4885HPGD 3351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.