Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16676752 | 0.89 | PARP10 (0.48) | BTKPARP10PARP14 | |
| SCHEMBL16671485 | 0.89 | BTK (0.44) | BTKPARP10PARP14RAB9ASYK | |
| SCHEMBL16671812 | 0.87 | BTK (0.47) | BTKCSF1RSYKTSHR | |
| SCHEMBL16670710 | 0.85 | BTK (0.45) | BTKSYK | |
| SCHEMBL16670822 | 0.84 | BTK (0.56) | BTKSYKTSHR | |
| SCHEMBL16670840 | 0.82 | CHRNB2 (0.48) | BTKSYK | |
| SCHEMBL28835246 | 0.81 | BTK (0.55) | BTKSYK | |
| SCHEMBL16671450 | 0.81 | BTK (0.64) | BTKSYK | |
| SCHEMBL16671805 | 0.81 | MEN1 (0.42) | BTKPARP10PARP14SYKTSHR | |
| SCHEMBL16671599 | 0.80 | BTK (0.71) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |