Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 16/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20973919 | 0.92 | ATF4 (0.63) | ATF4POLB | |
| SCHEMBL19569228 | 0.89 | ATF4 (0.50) | ATF4POLBSENP2ALDH1A1ALPL | |
| SCHEMBL20999295 | 0.88 | ATF4 (0.54) | ATF4POLBSENP2ALDH1A1MAPT | |
| SCHEMBL19569220 | 0.86 | ATF4 (0.55) | ATF4 | |
| SCHEMBL19569517 | 0.85 | ATF4 (0.52) | ATF4POLBSENP2ALDH1A1ALPL | |
| SCHEMBL19569443 | 0.85 | ATF4 (0.60) | ATF4 | |
| SCHEMBL19569216 | 0.84 | ATF4 (0.55) | ATF4 | |
| SCHEMBL19569219 | 0.84 | ATF4 (0.52) | ATF4 | |
| SCHEMBL19555483 | 0.84 | ATF4 (0.49) | ATF4 | |
| SCHEMBL19569606 | 0.84 | ATF4 (0.63) | ATF4POLBSENP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190144440-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144440-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ATF4 1/4885POLB 1764/4885SENP2 3515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.