Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 15/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569225 | 0.92 | ATF4 (0.53) | ATF4 | |
| SCHEMBL20999253 | 0.89 | ATF4 (0.52) | ATF4POLBSENP2ALDH1A1ALPL | |
| SCHEMBL20973919 | 0.89 | ATF4 (0.63) | ATF4POLB | |
| SCHEMBL30025520 | 0.81 | ATF4 (0.63) | ATF4POLBSENP2 | |
| SCHEMBL19569606 | 0.81 | ATF4 (0.63) | ATF4POLBSENP2 | |
| SCHEMBL19569427 | 0.81 | ATF4 (0.63) | ATF4POLBSENP2ALDH1A1 | |
| SCHEMBL30026213 | 0.81 | ATF4 (0.63) | ATF4POLBSENP2ALDH1A1 | |
| SCHEMBL20973825 | 0.81 | ATF4 (0.67) | ATF4 | |
| SCHEMBL19555483 | 0.79 | ATF4 (0.49) | ATF4 | |
| SCHEMBL21389960 | 0.79 | ATF4 (0.59) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |