Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732976 | 0.93 | HDAC1 (0.66) | HDAC1HDAC2L3MBTL1 | |
| SCHEMBL5583228 | 0.82 | DHFR (0.54) | MAPTDHFR | |
| SCHEMBL1065598 | 0.82 | HDAC1 (0.71) | HDAC1HDAC2L3MBTL1 | |
| SCHEMBL1060645 | 0.80 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL1064557 | 0.78 | HDAC1 (1.00) | HDAC1HDAC2 | |
| SCHEMBL13390608 | 0.75 | HDAC1 (0.60) | HDAC1HDAC2L3MBTL1 | |
| SCHEMBL2733855 | 0.75 | HDAC1 (0.68) | HDAC1HDAC2 | |
| SCHEMBL1080617 | 0.75 | HDAC1 (0.71) | HDAC1HDAC2L3MBTL1 | |
| SCHEMBL211640 | 0.74 | RAB9A (0.53) | MAPTL3MBTL1DHFR | |
| SCHEMBL212206 | 0.74 | HDAC1 (0.75) | HDAC1HDAC2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |