SCHEMBL21008151

SCHEMBL21008151

c1ccc2c(c1)sc1c2ccc2sc3c(-n4c5ccccc5c5ccccc54)ncnc3c21

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HRH4 Q9H3N8 2/20 0.45
▸ HTR2C P28335 1/20 0.45
▸ PIK3CA P42336 2/20 0.44
▸ LIMK1 P53667 5/20 0.42
▸ CDK5 Q00535 1/20 0.42
▸ CDK5R1 Q15078 1/20 0.42
▸ EGFR P00533 4/20 0.36
▸ MAPT P10636 2/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34
▸ HPGD P15428 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ GPR3 P46089 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21007302 0.89 HRH4 (0.46) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL16922590 0.85 HRH4 (0.59) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL21008240 0.83 GPR3 (0.34) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL21007301 0.83 KDM4E (0.40) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL24220032 0.82 HTR2C (0.44) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL21007009 0.80 ATM (0.42) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL21007300 0.79 LIMK1 (0.40) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL17030412 0.79 HTR2C (0.53) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL24056360 0.78 LIMK1 (0.42) HRH4HTR2CPIK3CALIMK1CDK5
SCHEMBL17030427 0.77 HRH4 (0.53) HRH4HTR2CPIK3CALIMK1CDK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11349081-B2 Azaindolocarbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2022-05-31 — — US disclosed
US-20190148646-A1 AZAINDOLOCARBAZOLE COMPOUNDS Beijing Summer Sprout Technology Co., Ltd. (CN) 2019-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190148646-A1 AZAINDOLOCARBAZOLE COMPOUNDS SLC25A21, OXA1L, OCIAD1 HRH4 2321/4885HTR2C 2510/4885PIK3CA 3428/4885
US-11349081-B2 Azaindolocarbazole compounds SLC25A21, OXA1L, OCIAD1 HRH4 2321/4885HTR2C 2510/4885PIK3CA 3428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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