Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 5/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CCND1 | P24385 | 3/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033751 | 0.79 | CTSK (0.60) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL91484 | 0.79 | CTSK (0.60) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL18920813 | 0.79 | CTSK (0.60) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL20606073 | 0.79 | CTSK (0.60) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL27109892 | 0.78 | CTSK (0.59) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL10187331 | 0.77 | CTSK (0.58) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL3451468 | 0.77 | CTSK (0.58) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL91478 | 0.77 | CTSK (0.58) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL27109893 | 0.77 | GPR39 (0.58) | CTSKKDM4EGAAHRH4CDK1 | |
| SCHEMBL15181307 | 0.76 | CTSK (0.56) | CTSKKDM4EGAAHRH4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47396-E1 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2019-05-21 | — | — | US | disclosed |