Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | SDHB | P21912 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23897438 | 0.90 | KDM4E (0.46) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL20985711 | 0.82 | KDM4E (0.47) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL29976621 | 0.82 | SDHB (0.59) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL19805635 | 0.82 | SDHB (0.59) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL29976249 | 0.81 | SDHB (0.54) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL19805905 | 0.81 | SDHB (0.54) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL19805732 | 0.78 | TP53 (0.49) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL29976339 | 0.78 | TP53 (0.49) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL29977092 | 0.78 | ADORA2A (0.53) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 | |
| SCHEMBL19805742 | 0.78 | ADORA2A (0.53) | ADORA2ASDHBKDM4EMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-20210309647-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-10-07 | — | — | US | disclosed |
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152960-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | ADORA2A 4749/4885SDHB 3/4885KDM4E 1117/4885 |
| US-11725000-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | ADORA2A 4749/4885SDHB 3/4885KDM4E 1117/4885 |
| US-11034680-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | ADORA2A 4749/4885SDHB 3/4885KDM4E 1117/4885 |
| US-20210309647-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | ADORA2A 4749/4885SDHB 3/4885KDM4E 1117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.