⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008729 | 0.78 | — | — | |
| SCHEMBL24333517 | 0.74 | KMT2A (0.31) | — | |
| SCHEMBL1106520 | 0.70 | PIK3CD (0.36) | — | |
| SCHEMBL1698512 | 0.68 | — | — | |
| SCHEMBL1106515 | 0.67 | BRD4 (0.39) | — | |
| SCHEMBL24687997 | 0.67 | BRD4 (0.39) | — | |
| SCHEMBL1106456 | 0.65 | MAPT (0.33) | — | |
| SCHEMBL12299946 | 0.65 | — | — | |
| SCHEMBL12395184 | 0.63 | CHRM2 (0.36) | — | |
| SCHEMBL596921 | 0.63 | PER2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210115018-A1 | PIPERIDINE COMPOUNDS AS COVALENT MENIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-04-22 | — | — | US | disclosed |
| US-20190152947-A1 | PIPERIDINES AS MENIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-05-23 | — | — | US | disclosed |