Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 known ✓ | P22455 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.34 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL28010442 | 0.97 | ALDH1A1 (0.55) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28009862 | 0.97 | ALDH1A1 (0.55) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL27617844 | 0.97 | ALDH1A1 (0.55) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28113151 | 0.90 | ALDH1A1 (0.58) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28749841 | 0.87 | TSHR (0.55) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL35701 | 0.86 | TSHR (0.48) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL27699998 | 0.84 | TSHR (0.46) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL10902779 | 0.84 | ALDH1A1 (0.58) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL19272435 | 0.83 | TSHR (0.65) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL432101 | 0.83 | TSHR (0.65) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104736236-B | The surface modification of porous matrix holder | 默克专利股份公司 | 2017-06-13 | — | — | CN | claimed |
| CN-104736236-A | Surface modification of porous base supports | MERCK PATENT GMBH | 2015-06-24 | — | — | CN | claimed |
| CN-113677318-B | Increasing the stability of agents for treating keratin materials | 汉高股份有限及两合公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-117651543-A | Method comprising dyeing keratin materials using an organosilicon compound, a dyeing compound, a blocking agent and an alkaline pretreatment agent | 汉高股份有限及两合公司 | 2024-03-05 | — | — | CN | disclosed |
| CN-117597105-A | Method for dyeing keratin materials comprising the use of an organosilicon compound, a polyethylene glycol, a dyeing compound and a post-treatment agent | 汉高股份有限及两合公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-117177732-A | Comprising the use of organic C 1 -C 6 Alkoxysilane, dyeing compound and method for dyeing heat-treated keratin materials | 汉高股份有限及两合公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-116940328-A | A method for dyeing keratin materials, which comprises using an organosilicon compound, a dyeing compound, a sealant and a pretreatment agent | 汉高股份有限及两合公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-116550312-A | Cationic chromatography medium and preparation method and application thereof | 博格隆(浙江)生物技术有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-116322623-A | Method for dyeing keratin materials comprising the use of an organosilicon compound, a colouring compound, a sealant and a pretreatment agent | 汉高股份有限及两合公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116157112-A | Process for dyeing keratin materials comprising the use of an organosilicon compound, a phosphate and a colouring agent compound | 汉高股份有限及两合公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-115243658-A | A process for coloring keratin materials comprising the use of an organosilicon compound, two coloring compounds and a post-treatment agent | 汉高股份有限及两合公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-1492753-A | Oxidizing composition for treating keratin materials, based on at least one ethylenically unsaturated monomer containing sulphonic groups and an amphiphilic polymer comprising hydrophobic portions | �ź㴫 | 2004-04-28 | — | — | CN | disclosed |
| CN-1406209-A | Stable silica sols with high surface area and improved activity | NALCO CHEMICAL CO (US) | 2003-03-26 | — | — | CN | disclosed |
| CN-1390319-A | Resin composition for toner and toner | MITSUI CHEMICALS INC (JP) | 2003-01-08 | — | — | CN | disclosed |
| EP-1262838-A1 | RESIN COMPOSITION FOR TONER AND TONER | Mitsui Chemicals, Inc. (JP) | 2002-12-04 | — | — | EP | disclosed |
| CN-1211259-A | Method for manufacture of low viscosity aqueous polymer dispersions with a polymer content of at least 50 volume% | BASF AG (DE) | 1999-03-17 | — | — | CN | disclosed |
| EP-0516305-B1 | Simultaneous use of water soluble polymers with ozone in cooling water systems | NALCO CHEMICAL CO (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5171451-A | Homo- and copolymers of (meth)acrylic acid and their salts; calcium carbonate saturation ratio retained; antiscaling agents, corrosion resistance | NALCO CHEMICAL COMPANY (US) | 1992-12-15 | — | — | US | disclosed |
| EP-0516305-A1 | Simultaneous use of water soluble polymers with ozone in cooling water systems | NALCO CHEMICAL COMPANY (US) | 1992-12-02 | — | — | EP | disclosed |
| CN-1042921-A | The manufacture method of absorbent composite, product and producing apparatus | NIPPON CATALYTIC CHEM IND (JP) | 1990-06-13 | — | — | CN | disclosed |