Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 known ✓ | P22455 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL2102098 | 0.97 | ALDH1A1 (0.58) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28010442 | 0.95 | ALDH1A1 (0.55) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28009862 | 0.95 | ALDH1A1 (0.55) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28113151 | 0.92 | ALDH1A1 (0.58) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL3731669 | 0.87 | — | — | |
| Acrylamide SCHEMBL28402180 | 0.87 | ALDH1A1 (0.73) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28749841 | 0.85 | TSHR (0.55) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL35701 | 0.84 | TSHR (0.48) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 | |
| Acrylamide SCHEMBL28124734 | 0.84 | — | — | |
| Acrylamide SCHEMBL27699998 | 0.82 | TSHR (0.46) | ALDH1A1TSHRFGFR4ZDHHC20ZDHHC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100471900-C | Method of producing particle-shape water-absorbing resin material | NIPPON CATALYTIC CHEM IND (JP) | 2009-03-25 | — | — | CN | disclosed |
| CN-1611529-A | Method of producing particle-shape water-absorbing resin material | NIPPON CATALYTIC CHEM IND (JP) | 2005-05-04 | — | — | CN | disclosed |