Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22796684 | 0.88 | AR (0.42) | ARSLC6A4TRPV4BRD9BRD1 | |
| SCHEMBL18923587 | 0.88 | AR (0.44) | ARSLC6A4CTSATRPV4KDM1A | |
| SCHEMBL171796 | 0.84 | AR (0.47) | ARSLC6A4CTSAKDM1AICMT | |
| SCHEMBL523615 | 0.80 | AR (0.49) | ARSLC6A4KDM1AICMTBRD9 | |
| SCHEMBL19068977 | 0.78 | SCN1A (0.40) | TRPV4MEN1KMT2A | |
| SCHEMBL19389253 | 0.78 | CYP2D6 (0.56) | MEN1KMT2A | |
| SCHEMBL20855587 | 0.78 | AR (0.46) | ARSLC6A4TRPV4KDM1AICMT | |
| SCHEMBL20855659 | 0.78 | AR (0.46) | ARSLC6A4CTSAKDM1AMEN1 | |
| SCHEMBL20855762 | 0.78 | AR (0.46) | ARSLC6A4KDM1AICMTMEN1 | |
| SCHEMBL16955918 | 0.78 | AR (0.46) | ARSLC6A4CTSAKDM1AICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10426135-B2 | Methyl- and trifluromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof | PFIZER INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20190150401-A1 | Methyl- and Trifluromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof | PFIZER INC. (US) | 2019-05-23 | — | — | US | disclosed |