Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 10/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12712612 | 0.84 | PDK4 (0.69) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL3436385 | 0.84 | PDK4 (0.69) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL2882861 | 0.83 | PDK4 (0.68) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL17268510 | 0.83 | PDK4 (0.68) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL30135250 | 0.83 | PDK4 (0.68) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL83700 | 0.83 | PDK4 (0.68) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL30061046 | 0.83 | PDK4 (0.68) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL3642397 | 0.83 | PDK4 (0.68) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL4701991 | 0.82 | PDK4 (0.67) | PDK4HTR6GRM5GRM1NAMPT | |
| SCHEMBL4859866 | 0.82 | PDK4 (0.67) | PDK4HTR6GRM5GRM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163737-B2 | CGRP receptor antagonists | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163737-B2 | CGRP receptor antagonists | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163737-B2 | CGRP receptor antagonists | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090176769-A1 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-07-09 | — | — | US | disclosed |
| US-20090176769-A1 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-07-09 | — | — | US | disclosed |
| US-20090176769-A1 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-07-09 | — | — | US | disclosed |
| WO-2009020470-A2 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-02-12 | — | — | WO | disclosed |
| US-7115633-B2 | Central nervous system disorders; Alzheimer's diseases; eating disorders | GLAXOSMITHKLINE S.P.A. (IT) | 2006-10-03 | — | — | US | disclosed |
| EP-1278729-B1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GLAXOSMITHKLINE SPA (IT) | 2005-11-09 | — | — | EP | disclosed |
| US-20040029917-A1 | Benzosuberonylpiperdine compounds as analgesics | GLAXOSMITHKLINE S.P.A. (IT) | 2004-02-12 | — | — | US | disclosed |
| EP-1278729-A1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GlaxoSmithKline S.p.A. (IT) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083454-A1 | BENZOSUBERONYLPIPERIDINE COMPOUNDS AS ANALGESICS | GLAXOSMITHKLINE S.P.A. (IT) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176769-A1 | CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, GRPR | PDK4 4302/4885HTR6 252/4885GRM5 317/4885 |
| US-20040029917-A1 | Benzosuberonylpiperdine compounds as analgesics | OPRK1, OPRL1, OPRM1 | PDK4 2157/4885HTR6 28/4885GRM5 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.