Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | LPO | P22079 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27895992 | 1.00 | TLR8 (0.41) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL19087084 | 1.00 | TLR8 (0.41) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL28717092 | 0.98 | TLR8 (0.40) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL20098274 | 0.98 | TLR8 (0.40) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL28717680 | 0.97 | TLR8 (0.41) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL20372906 | 0.97 | TLR8 (0.41) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL20994722 | 0.93 | TLR8 (0.39) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL1854500 | 0.92 | TLR8 (0.40) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL19582677 | 0.86 | L3MBTL1 (0.40) | TLR8L3MBTL1ALDH1A1POLBKMT2A | |
| SCHEMBL28942503 | 0.85 | L3MBTL1 (0.46) | TLR8L3MBTL1ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524963-B2 | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-11008314-B2 | Compounds and methods for modulating interleukin-2-inducible t-cell kinase | CORVUS PHARMACEUTICALS, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| US-20200399279-A1 | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2020-12-24 | — | — | US | disclosed |
| US-10647711-B2 | Azepin-2-one derivatives as RSV inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190152968-A1 | AZEPIN-2-ONE DERIVATIVES AS RSV INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152968-A1 | AZEPIN-2-ONE DERIVATIVES AS RSV INHIBITORS | AZI2, FURIN, ACE2 | TLR8 2165/4885L3MBTL1 4854/4885ALDH1A1 1328/4885 |
| US-11008314-B2 | Compounds and methods for modulating interleukin-2-inducible t-cell kinase | IL2, NFATC1, IL2RA | TLR8 684/4885L3MBTL1 1737/4885ALDH1A1 3523/4885 |
| US-20200399279-A1 | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | TLR8 3790/4885L3MBTL1 1165/4885ALDH1A1 1787/4885 |
| US-11524963-B2 | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors | RET, ROR1, BRAF | TLR8 3744/4885L3MBTL1 1212/4885ALDH1A1 1752/4885 |
| US-10647711-B2 | Azepin-2-one derivatives as RSV inhibitors | AZI2, FURIN, ACE2 | TLR8 2165/4885L3MBTL1 4854/4885ALDH1A1 1328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.