Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102307 | 0.85 | EPHX2 (0.35) | LRRK2EPHX2CYP2D6HRH1KCNH2 | |
| SCHEMBL57030 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL28314935 | 0.76 | — | — | |
| SCHEMBL574344 | 0.74 | EPHX2 (0.38) | EPHX2CYP2D6HRH1KCNH2ELOVL1 | |
| SCHEMBL13890730 | 0.74 | — | — | |
| SCHEMBL14722189 | 0.74 | EPHX2 (0.33) | EPHX2CYP2D6HRH1KCNH2ELOVL1 | |
| SCHEMBL8256361 | 0.73 | PDK1 (0.36) | EPHX2CYP2D6HRH1KCNH2ELOVL1 | |
| SCHEMBL22188114 | 0.73 | PDK1 (0.36) | EPHX2CYP2D6HRH1KCNH2ELOVL1 | |
| SCHEMBL26022733 | 0.73 | ELOVL1 (0.35) | LRRK2EPHX2ELOVL1HCAR2 | |
| SCHEMBL3434555 | 0.72 | EPHX2 (0.38) | EPHX2CYP2D6HRH1KCNH2ELOVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119765-B1 | HETEROARYL SYK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-07-17 | — | — | EP | disclosed |
| EP-3119772-B1 | HETEROARYL SIK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-05-22 | — | — | EP | disclosed |