Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9607146 | 1.00 | APP (0.48) | APPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12723382 | 0.93 | HSD11B1 (0.43) | APPHSD11B1 | |
| SCHEMBL9607147 | 0.88 | APP (0.47) | APPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13556269 | 0.84 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL21025285 | 0.81 | HSD11B1 (0.42) | APPALDH1A1HSD11B1 | |
| SCHEMBL9607276 | 0.76 | APP (0.45) | APPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20107545 | 0.76 | APP (0.45) | APPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13556274 | 0.72 | HSD11B1 (0.38) | ALDH1A1HSD11B1 | |
| SCHEMBL2952559 | 0.71 | APP (0.55) | APPPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7002284 | 0.71 | APP (0.55) | APPPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3485883-A1 | METHODS OF TREATING EYE DISEASES ASSOCIATED WITH INFLAMMATION AND VASCULAR PROLIFERATION | OccuRx Pty Ltd (AU) | 2019-05-22 | — | — | EP | disclosed |