Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.50 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.47 |
| ▸ | TUBB | P07437 | 2/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002288 | 1.00 | APP (0.55) | APPCA1CA2CA9CA12 | |
| SCHEMBL2952559 | 1.00 | APP (0.55) | APPCA1CA2CA9CA12 | |
| SCHEMBL7003488 | 0.88 | RXRA (0.49) | APPCA1CA2CA9CA12 | |
| SCHEMBL10254282 | 0.88 | RXRA (0.49) | APPCA1CA2CA9CA12 | |
| SCHEMBL7002924 | 0.88 | RXRA (0.49) | APPCA1CA2CA9CA12 | |
| SCHEMBL13001927 | 0.87 | PDE4B (0.52) | APPPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL22714051 | 0.86 | PDE4B (0.58) | APPCA1CA2CA9CA12 | |
| SCHEMBL7366496 | 0.86 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7366497 | 0.86 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6996736 | 0.86 | ALDH1A1 (0.52) | APPCA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996621-B1 | TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | EP | disclosed |
| US-6251910-B1 | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists | ASTRAZENECA UK LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |