⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24843107 | 0.76 | ADH1B (0.32) | — | |
| SCHEMBL19228201 | 0.72 | CYP2D6 (0.33) | — | |
| SCHEMBL3421028 | 0.70 | ADH1B (0.38) | — | |
| SCHEMBL23750515 | 0.69 | — | — | |
| SCHEMBL270919 | 0.69 | — | — | |
| SCHEMBL18802050 | 0.69 | — | — | |
| SCHEMBL29320305 | 0.67 | — | — | |
| SCHEMBL21106238 | 0.65 | HRH4 (0.40) | — | |
| SCHEMBL21789666 | 0.65 | — | — | |
| SCHEMBL3698430 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2019-05-23 | — | — | US | disclosed |