Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | SOD1 | P00441 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325681 | 1.00 | MTNR1A (0.44) | MTNR1AMTNR1BFFAR1SOD1KDM4E | |
| SCHEMBL21026219 | 0.86 | MTNR1A (0.43) | MTNR1AMTNR1BFFAR1SOD1LMNA | |
| SCHEMBL18591787 | 0.86 | MTNR1A (0.43) | MTNR1AMTNR1BFFAR1SOD1LMNA | |
| SCHEMBL18591764 | 0.86 | MTNR1A (0.43) | MTNR1AMTNR1BFFAR1SOD1LMNA | |
| SCHEMBL21341711 | 0.84 | MTNR1A (0.42) | MTNR1AMTNR1BFFAR1SOD1KDM4E | |
| SCHEMBL12293429 | 0.82 | GPBAR1 (0.44) | MTNR1AMTNR1BFFAR1SOD1LMNA | |
| SCHEMBL21574459 | 0.79 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4ENSD2ALDH1A1 | |
| SCHEMBL18551176 | 0.79 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4ENSD2ALDH1A1 | |
| SCHEMBL18551166 | 0.79 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4ENSD2ALDH1A1 | |
| SCHEMBL24856091 | 0.78 | SOD1 (0.40) | MTNR1AMTNR1BFFAR1SOD1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | IRAK1, IRAK4, IRAK2 | MTNR1A 1897/4885MTNR1B 1818/4885FFAR1 3121/4885 |
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | MTNR1A 1897/4885MTNR1B 1818/4885FFAR1 3121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.