⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6835524 | 0.68 | — | — | |
| SCHEMBL1040558 | 0.65 | — | — | |
| SCHEMBL17923692 | 0.63 | ALDH1A1 (0.32) | — | |
| SCHEMBL2527445 | 0.63 | — | — | |
| SCHEMBL1533620 | 0.62 | — | — | |
| SCHEMBL5045911 | 0.61 | — | — | |
| SCHEMBL9558214 | 0.60 | — | — | |
| SCHEMBL8616259 | 0.59 | — | — | |
| SCHEMBL709852 | 0.58 | MAPT (0.39) | — | |
| SCHEMBL111083 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | claimed |
| EP-0710661-B1 | Amino acid derivative having anti-CKK activity | TOBISHI PHARMACEUTICAL CO (JP) | 1999-03-31 | — | — | EP | claimed |
| EP-0710661-A1 | Amino acid derivative having anti-CKK activity | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1996-05-08 | — | — | EP | claimed |
| EP-0314852-B1 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA GEIGY AG (CH) | 1993-11-18 | — | — | EP | claimed |
| EP-0511270-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1992-11-04 | — | — | EP | claimed |
| EP-0207563-B1 | A METHOD FOR CONTROLLING WEEDS | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-31 | — | — | EP | claimed |
| WO-1991010657-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-07-25 | — | — | WO | claimed |
| EP-0314852-A2 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA-GEIGY AG (CH) | 1989-05-10 | — | — | EP | claimed |
| EP-0289066-A1 | 1,5-Substituted 1H-imidazoles | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-11-02 | — | — | EP | claimed |
| EP-0277384-A2 | 1H-imidazole-5-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-10 | — | — | EP | claimed |
| EP-0207563-A2 | A method for controlling weeds | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-01-07 | — | — | EP | claimed |
| EP-3180003-B1 | PKC-EPSILON INHIBITORS | UNIV CALIFORNIA (US) | 2022-01-12 | — | — | EP | disclosed |
| US-11072628-B2 | Nucleoside analogues for the treatment of parasitic infections | UNIVERSITEIT GENT (BE) | 2021-07-27 | — | — | US | disclosed |
| US-10377772-B2 | Macrocyclic LRRK2 kinase inhibitors | ONCODESIGN S.A. (FR) | 2019-08-13 | — | — | US | disclosed |
| EP-3194405-B1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | ONCODESIGN SA (FR) | 2018-12-26 | — | — | EP | disclosed |
| EP-0289066-A1 | 1,5-Substituted 1H-imidazoles | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-11-02 | — | — | EP | disclosed |
| EP-0277384-A2 | 1H-imidazole-5-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-10 | — | — | EP | disclosed |
| EP-0277384-A2 | 1H-imidazole-5-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-10 | — | — | EP | disclosed |
| EP-0207563-A2 | A method for controlling weeds | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-01-07 | — | — | EP | disclosed |
| EP-0207563-A2 | A method for controlling weeds | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-01-07 | — | — | EP | disclosed |