⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17923692 | 0.82 | ALDH1A1 (0.32) | — | |
| SCHEMBL9205277 | 0.79 | — | — | |
| SCHEMBL7724071 | 0.78 | FGFR1 (0.32) | — | |
| SCHEMBL5685518 | 0.76 | FGFR1 (0.33) | — | |
| SCHEMBL11176419 | 0.73 | — | — | |
| SCHEMBL6682147 | 0.73 | CYP3A4 (0.31) | — | |
| SCHEMBL5850276 | 0.73 | — | — | |
| SCHEMBL5549235 | 0.71 | P2RX7 (0.33) | — | |
| SCHEMBL6684629 | 0.70 | — | — | |
| SCHEMBL6682019 | 0.69 | CASP3 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648707-A1 | HYDROXYLATED TRICYCLIC COMPOUNDS | Nektar Therapeutics (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012079017-A1 | HYDROXYLATED TRICYCLIC COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2012-06-14 | — | — | WO | disclosed |
| US-7361668-B2 | Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors | UCB, S.A. (BE) | 2008-04-22 | — | — | US | disclosed |
| US-7112696-B2 | Preparation of phosphorus compounds | BAYER CHEMICALS AG (DE) | 2006-09-26 | — | — | US | disclosed |
| US-20050020660-A1 | Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors | UCB, S.A. (BE) | 2005-01-27 | — | — | US | disclosed |
| US-20050020835-A1 | Preparation of phosphorus compounds | LANXESS DEUTSCHLAND GMBH (DE) | 2005-01-27 | — | — | US | disclosed |
| EP-1475384-A1 | Process for preparing phosphorus compounds | Bayer Chemicals AG (DE) | 2004-11-10 | — | — | EP | disclosed |
| EP-0307303-B1 | 1-[(2-Pyrimidinyl)-aminoalkyl] piperidines, their preparation and their use in therapy | SYNTHELABO (FR) | 1991-12-04 | — | — | EP | disclosed |
| EP-0307303-A1 | 1-[(2-Pyrimidinyl)-aminoalkyl] piperidines, their preparation and their use in therapy | SYNTHELABO (FR) | 1989-03-15 | — | — | EP | disclosed |
| US-4083997-A | ANTIDEPRESSANTS | SANDOZ, INC. (US) | 1978-04-11 | — | — | US | disclosed |
| US-3994961-A | ANTIDEPRESSANTS | SANDOZ, INC. (US) | 1976-11-30 | — | — | US | disclosed |
| US-3925476-A | 10-(2-Dialkylaminoethyl)-10,11-dihydro, or 10-(2-dialkylaminoethyl)-5-methylene-2,7-substituted or unsubstituted-5H-dibenzo{8 a,d{9 cycloheptenes | SANDOZ AG | 1975-12-09 | — | — | US | disclosed |