SCHEMBL21026421

SCHEMBL21026421

CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCC(c3ccc4c(Cl)noc4c3)CC2)CC1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 16/20 0.60
DRD3 P35462 16/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21026228 0.86 DRD3 (0.57) HTR2ADRD3
SCHEMBL21026223 0.82 HTR2A (0.82) HTR2ADRD3
SCHEMBL21026348 0.77 DRD3 (0.61) HTR2ADRD3
SCHEMBL21026469 0.77 DRD3 (0.54) HTR2ADRD3
SCHEMBL21026108 0.77 DRD3 (0.61) HTR2ADRD3
SCHEMBL4202827 0.75 HTR2A (1.00) HTR2ADRD3
SCHEMBL15859550 0.75 HTR2A (1.00) HTR2ADRD3
SCHEMBL21729945 0.74 DRD2 (0.69) HTR2ADRD3
SCHEMBL604688 0.73 HTR2A (1.00) HTR2ADRD3
SCHEMBL15866499 0.73 HTR2A (1.00) HTR2ADRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10301277-B2 Substituted ureas and methods of treating mental illness using the same ZHEJIANG JINGXIN PHARMACEUTICAL CO., LTD. (CN) 2019-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10301277-B2 Substituted ureas and methods of treating mental illness using the same CRHR1, UTS2R, HTR2C HTR2A 23/4885DRD3 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.