Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18855227 | 0.89 | MAPT (0.49) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL14397927 | 0.78 | RAB9A (0.45) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL232012 | 0.78 | MAPT (0.55) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL14757505 | 0.77 | MAPT (0.50) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL19216317 | 0.73 | MAPT (0.50) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL19779317 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1 | |
| SCHEMBL12640005 | 0.73 | MAPT (0.42) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL15306569 | 0.71 | MAPT (0.47) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL179317 | 0.71 | MAPT (0.47) | MAPTRAB9ANPC1ATMSMN1; SMN2 | |
| SCHEMBL10162160 | 0.71 | L3MBTL1 (0.47) | MAPTRAB9ANPC1ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240452-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES AS PI3 KINASE MODULATORS, THEIR COMPOSITIONS AND USES | INTELLIKINE LLC (US) | 2019-05-29 | — | — | EP | disclosed |