Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FER | P16591 | 6/20 | 0.44 |
| ▸ | SYK | P43405 | 13/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | HCK | P08631 | 2/20 | 0.40 |
| ▸ | ROS1 | P08922 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | MARK3 | P27448 | 2/20 | 0.40 |
| ▸ | LTK | P29376 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20173714 | 0.83 | SYK (0.56) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL1987593 | 0.81 | FER (0.47) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL22475441 | 0.81 | FER (0.47) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL21032281 | 0.81 | FER (0.51) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL1986771 | 0.80 | SYK (0.51) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL22475480 | 0.79 | MKNK2 (0.35) | LRRK2MKNK2 | |
| SCHEMBL23397919 | 0.74 | FER (0.38) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL16751294 | 0.73 | FER (0.40) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL16751306 | 0.73 | FER (0.54) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL21032765 | 0.73 | SYK (0.67) | FERSYKJAK2ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3825316-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2021-05-26 | — | — | EP | disclosed |
| EP-3489236-A1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | Takeda Pharmaceutical Company Limited (JP) | 2019-05-29 | — | — | EP | disclosed |