Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.56 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.44 |
| ▸ | FER | P16591 | 7/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178206 | 0.87 | SYK (0.42) | SYKFERCDK1 | |
| SCHEMBL22475441 | 0.85 | FER (0.47) | SYKJAK2FERRETALK | |
| SCHEMBL1987593 | 0.85 | FER (0.47) | SYKJAK2FERRETALK | |
| SCHEMBL21032272 | 0.83 | FER (0.44) | SYKJAK2ZAP70FERRET | |
| SCHEMBL21032281 | 0.80 | FER (0.51) | SYKJAK2ZAP70FERRET | |
| SCHEMBL1986771 | 0.79 | SYK (0.51) | SYKJAK2ZAP70FERRET | |
| SCHEMBL20173713 | 0.79 | F11 (0.46) | SYKCDK1CLK4DYRK1B | |
| SCHEMBL16751292 | 0.76 | ALDH1A1 (0.40) | SYKFERRETCDC7ROCK2 | |
| SCHEMBL20173715 | 0.74 | SYK (0.67) | SYKJAK2ZAP70FERRET | |
| SCHEMBL23397919 | 0.74 | FER (0.38) | SYKJAK2ZAP70FERRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141951-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | CALITHERA BIOSCIENCES, INC. | 2018-05-24 | — | — | US | disclosed |
| US-20180141951-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | CALITHERA BIOSCIENCES, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141951-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | SYK, ZAP70, LYN | SYK 1/4885JAK2 5/4885ZAP70 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.