Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28113274 | 0.83 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8516579 | 0.83 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8516578 | 0.83 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL19472472 | 0.81 | HCAR2 (0.36) | PDK2HCAR2ALDH1A1LMNACES2 | |
| SCHEMBL361957 | 0.81 | PDK1 (0.44) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL4672249 | 0.80 | HCAR2 (0.39) | HCAR2ALDH1A1LMNAESR1CHRM1 | |
| SCHEMBL19105203 | 0.80 | HCAR2 (0.39) | HCAR2ALDH1A1LMNACES2ESR1 | |
| SCHEMBL2607867 | 0.80 | HCAR2 (0.39) | HCAR2ALDH1A1LMNACES2ESR1 | |
| SCHEMBL2691400 | 0.78 | HCAR2 (0.38) | PDK2HCAR2ALDH1A1LMNACES2 | |
| SCHEMBL29197988 | 0.78 | HCAR2 (0.38) | PDK2HCAR2ALDH1A1LMNACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399995-B2 | 1,4-Oxazines useful as selective BACE1 inhibitors | ELI LILLY AND COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-20190161502-A1 | 1,4-OXAZINES USEFUL AS SELECTIVE BACE1 INHIBITORS | LILLY CO ELI (US) | 2019-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399995-B2 | 1,4-Oxazines useful as selective BACE1 inhibitors | BACE1, BACE2, PSEN1 | PDK1 3189/4885PDK2 3214/4885PDK3 3056/4885 |
| US-20190161502-A1 | 1,4-OXAZINES USEFUL AS SELECTIVE BACE1 INHIBITORS | BACE1, BACE2, PSEN1 | PDK1 3189/4885PDK2 3214/4885PDK3 3056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.