SCHEMBL21033403

SCHEMBL21033403

Cc1ccc(S(=O)(=O)c2cc3cc(Br)cc(Br)c3oc2=O)cc1C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 3/20 0.55
RXFP1 Q9HBX9 3/20 0.53
TP53 P04637 2/20 0.53
PKM P14618 4/20 0.51
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
LMNA P02545 3/20 0.51
NPSR1 Q6W5P4 2/20 0.51
CRHBP P24387 1/20 0.49
CRHR2 Q13324 1/20 0.49
MAPT P10636 2/20 0.45
MAOB P27338 4/20 0.45
GPR35 Q9HC97 2/20 0.43
MAOA P21397 2/20 0.43
PABPC1 P11940 1/20 0.43
ERAP1 Q9NZ08 1/20 0.43
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.40
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21033402 0.82 RXFP1 (0.55) ATMRXFP1TP53PKMMEN1
SCHEMBL21033056 0.81 RXFP1 (0.64) RXFP1TP53PKMMEN1KMT2A
SCHEMBL21033400 0.81 LMNA (0.69) ATMRXFP1TP53PKMMEN1
SCHEMBL21033631 0.81 LMNA (0.77) ATMRXFP1TP53PKMMEN1
SCHEMBL831076 0.76 RXFP1 (0.51) ATMRXFP1TP53PKMMEN1
SCHEMBL21033130 0.76 RXFP1 (0.69) ATMRXFP1TP53PKMMEN1
SCHEMBL21555374 0.74 RXFP1 (0.75) ATMRXFP1TP53PKMMEN1
SCHEMBL21032751 0.73 CA12 (0.65) ATMRXFP1TP53PKMMEN1
SCHEMBL21033632 0.71 ATM (0.62) ATMRXFP1TP53PKMMEN1
SCHEMBL20435640 0.71 MAPT (0.74) ATMRXFP1TP53PKMMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019104201-A1 SMALL MOLECULE AGONISTS AND ANTAGONISTS OF NR2F6 ACTIVITY IN NON-HUMANS Zander Therapeutics, Inc. (US) 2019-05-31 WO disclosed
WO-2019104199-A1 SMALL MOLECULE AGONISTS AND ANTAGONISTS OF NR2F6 ACTIVITY REGEN BIOPHARMA INC. (US) 2019-05-31 WO disclosed