Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.51 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16672585 | 0.84 | CNR2 (0.49) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL3533288 | 0.79 | MEN1 (0.49) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL21034080 | 0.79 | KMT2A (0.47) | MEN1KMT2ALMNAPOLBGAA | |
| SCHEMBL14874379 | 0.76 | MEN1 (0.44) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL17102000 | 0.75 | KMT2A (0.49) | MEN1KMT2ALMNAPOLBGAA | |
| SCHEMBL21034081 | 0.75 | MEN1 (0.43) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL314187 | 0.75 | MEN1 (0.43) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL15974376 | 0.75 | MEN1 (0.43) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL9275981 | 0.74 | MAPT (0.50) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL30039482 | 0.74 | MAPT (0.50) | MEN1KMT2AMAPTPLIN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111372936-B | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-111372936-A | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-110452253-A | Mcl-1 selective depressant and its preparation and use | CENTAURUS BIOPHARMA CO LTD | 2019-11-15 | — | — | CN | disclosed |
| WO-2019101144-A1 | SELECTIVE MCL-1 INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2019-05-31 | — | — | WO | disclosed |
| CN-109824690-A | Mcl-1 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-05-31 | — | — | CN | disclosed |