Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.43 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033758 | 0.84 | ATM (0.44) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL30038752 | 0.84 | ATM (0.44) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL16672585 | 0.77 | CNR2 (0.49) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL9369385 | 0.76 | PIN1 (0.47) | MEN1KMT2APOLBCYP1A2SMN1; SMN2 | |
| SCHEMBL21034066 | 0.76 | KMT2A (0.49) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL14874522 | 0.75 | POLB (0.44) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL14874379 | 0.75 | MEN1 (0.44) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL21034079 | 0.75 | MEN1 (0.51) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL14874397 | 0.74 | KMT2A (0.47) | MEN1KMT2ALMNAPLIN1POLB | |
| SCHEMBL15974376 | 0.73 | MEN1 (0.43) | MEN1KMT2ALMNAPLIN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111372936-B | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-111372936-A | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2020-07-03 | — | — | CN | disclosed |
| WO-2019101144-A1 | SELECTIVE MCL-1 INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2019-05-31 | — | — | WO | disclosed |