Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17102000 | 0.85 | KMT2A (0.49) | KMT2AMEN1ALDH1A1GAACA12 | |
| SCHEMBL12260657 | 0.81 | ATM (0.46) | KMT2AMEN1ALDH1A1GAACA12 | |
| SCHEMBL27471238 | 0.80 | GAA (0.49) | KMT2AMEN1ALDH1A1GAACA12 | |
| SCHEMBL18493202 | 0.80 | KMT2A (0.50) | KMT2AMEN1ALDH1A1GAACA12 | |
| SCHEMBL21034079 | 0.79 | MEN1 (0.51) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL6404528 | 0.76 | KMT2A (0.51) | KMT2AMEN1ALDH1A1GAACA12 | |
| SCHEMBL420634 | 0.76 | KMT2A (0.51) | KMT2AMEN1ALDH1A1GAACA12 | |
| SCHEMBL11023514 | 0.75 | KMT2A (0.47) | KMT2AMEN1ALDH1A1GAACA12 | |
| SCHEMBL16672585 | 0.75 | CNR2 (0.49) | KMT2AMEN1GAAPOLBLMNA | |
| SCHEMBL9577269 | 0.74 | KCNN4 (0.41) | KMT2AALDH1A1POLBL3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111372936-B | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-111372936-A | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2020-07-03 | — | — | CN | disclosed |
| CN-110452253-A | Mcl-1 selective depressant and its preparation and use | CENTAURUS BIOPHARMA CO LTD | 2019-11-15 | — | — | CN | disclosed |
| WO-2019101144-A1 | SELECTIVE MCL-1 INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2019-05-31 | — | — | WO | disclosed |
| CN-109824690-A | Mcl-1 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-05-31 | — | — | CN | disclosed |