Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.54 |
| ▸ | MET | P08581 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17610081 | 0.89 | CYP11B1 (0.47) | CYP11B1CYP11B2METAURKAABL1 | |
| SCHEMBL1549465 | 0.83 | GRM2 (0.50) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9602018 | 0.81 | NPC1 (0.61) | CYP11B1CYP11B2METAURKAABL1 | |
| SCHEMBL26316731 | 0.81 | AURKA (0.54) | CYP11B1CYP11B2METAURKAABL1 | |
| SCHEMBL2216313 | 0.81 | FYN (0.56) | CYP11B1CYP11B2METAURKAABL1 | |
| SCHEMBL317352 | 0.81 | CYP11B1 (0.54) | CYP11B1CYP11B2METAURKAABL1 | |
| SCHEMBL317351 | 0.81 | CYP11B1 (0.54) | CYP11B1CYP11B2METAURKAABL1 | |
| SCHEMBL2411349 | 0.81 | CYP11B1 (0.59) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8382983 | 0.81 | CYP11B1 (0.57) | CYP11B1CYP11B2METAURKAABL1 | |
| SCHEMBL1550000 | 0.81 | CYP11B1 (0.49) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019104011-A1 | CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2019-05-31 | — | — | WO | disclosed |