Sugi Predict

Sugi Predict / Compounds / SCHEMBL1550000

SCHEMBL1550000

SCHEMBL1550000

FC(F)(F)c1ccc(-c2ccc(CCl)cn2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP11B1 P15538 2/20 0.49
▸ CYP11B2 P19099 2/20 0.49
▸ MAOB P27338 2/20 0.49
▸ KDM1A O60341 2/20 0.49
▸ PPARA Q07869 1/20 0.47
▸ KIF11 P52732 3/20 0.44
▸ LTA4H P09960 1/20 0.43
▸ EPHB4 P54760 2/20 0.41
▸ TEK Q02763 2/20 0.41
▸ KDR P35968 1/20 0.41
▸ HDAC1 Q13547 1/20 0.39
▸ MIF P14174 1/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ NFKB1 P19838 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ NFKB2 Q00653 1/20 0.39
▸ RELA Q04206 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL31375590 0.98 CYP11B1 (0.48) CYP11B1CYP11B2MAOBKDM1APPARA
SCHEMBL30462004 0.90 KIF11 (0.51) CYP11B1CYP11B2MAOBKDM1APPARA
SCHEMBL3387516 0.90 KIF11 (0.51) CYP11B1CYP11B2MAOBKDM1APPARA
Hydrochloric Acid SCHEMBL31453978 0.89 KIF11 (0.50) CYP11B1CYP11B2MAOBKDM1APPARA
SCHEMBL30633001 0.83 PPARA (0.50) CYP11B1CYP11B2MAOBKDM1APPARA
SCHEMBL2056329 0.83 RAB9A (0.56) CYP11B1CYP11B2MAOBKDM1APPARA
SCHEMBL1549725 0.83 PPARA (0.50) CYP11B1CYP11B2MAOBKDM1APPARA
SCHEMBL4592034 0.81 KDM1A (0.53) CYP11B1CYP11B2MAOBKDM1ATEK
SCHEMBL21035639 0.81 CYP11B1 (0.54) CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2
SCHEMBL9351438 0.81 SMN1; SMN2 (0.58) CYP11B1CYP11B2MAOBKDM1APPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568960-B1 BICYCLIC TETRAHYDROAZEPINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2026-04-29 — — EP disclosed
US-20260035364-A1 BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2026-02-05 — — US disclosed
US-20250236614-A1 BICYCLIC TETRAHYDROAZEPINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2025-07-24 — — US disclosed
EP-4568960-A1 BICYCLIC TETRAHYDROAZEPINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2025-06-18 — — EP disclosed
EP-4568959-A1 BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2025-06-18 — — EP disclosed
US-12286426-B2 Heterocyclic mitochondrial activity inhibitors and uses thereof Université de Montréal (CA) 2025-04-29 — — US disclosed
CN-119677733-A Bicyclic tetrahydrothiazepine derivatives 豪夫迈·罗氏有限公司 2025-03-21 — — CN disclosed
EP-3704111-B1 HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF UNIV MONTREAL (CA) 2024-10-09 — — EP disclosed
WO-2024033458-A1 BICYCLIC TETRAHYDROAZEPINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2024-02-15 — — WO disclosed
CN-111886234-B Heterocyclic mitochondrial activity inhibitors and uses thereof 蒙特利尔大学 2023-12-15 — — CN disclosed
US-7429605-B2 Phenylpyridine derivatives HOFFMANN-LA ROCHE INC. (US) 2008-09-30 — — US disclosed
CN-101213186-A Phenylpyridine derivatives, their manufacture and use as pharmaceutical agents HOFFMANN LA ROCHE (CH) 2008-07-02 — — CN disclosed
EP-1912969-A1 PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2008-04-23 — — EP disclosed
WO-2007017169-A1 PHENYLPYRIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2007-02-15 — — WO disclosed
US-20070032530-A1 Phenylpyridine derivatives HOFFMANN-LA ROCHE INC. 2007-02-08 — — US disclosed
CN-1875002-A Phenyl derivatives as PPAR agonists HOFFMANN LA ROCHE (CH) 2006-12-06 — — CN disclosed
US-7115611-B2 Phenyl derivatives, their manufacture and use as pharmaceutical agents HOFFMANN-LA ROCHE INC. (US) 2006-10-03 — — US disclosed
EP-1682508-A1 PHENYL DERIVATIVES AS PPAR AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2006-07-26 — — EP disclosed
WO-2005049573-A1 PHENYL DERIVATIVES AS PPAR AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-06-02 — — WO disclosed
US-20050096337-A1 Phenyl derivatives, their manufacture and use as pharmaceutical agents HOFFMANN-LA ROCHE INC. 2005-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032530-A1 Phenylpyridine derivatives CYP3A5, QDPR, DPYD CYP11B1 127/4885CYP11B2 103/4885MAOB 211/4885
US-20050096337-A1 Phenyl derivatives, their manufacture and use as pharmaceutical agents PPARD, PPARA, PPARG CYP11B1 65/4885CYP11B2 126/4885MAOB 1861/4885
US-20250236614-A1 BICYCLIC TETRAHYDROAZEPINE DERIVATIVES GRIN2C, CNR1, CNR2 CYP11B1 147/4885CYP11B2 137/4885MAOB 325/4885
US-20260035364-A1 BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES SCN1B, SCN2B, SCN11A CYP11B1 174/4885CYP11B2 187/4885MAOB 462/4885
US-12286426-B2 Heterocyclic mitochondrial activity inhibitors and uses thereof IDH2, TFAM, IDH1 CYP11B1 43/4885CYP11B2 36/4885MAOB 3874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.