Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27027458 | 0.83 | ATM (0.31) | ATM | |
| SCHEMBL12325470 | 0.79 | GBA1 (0.38) | GBA1EIF2AK4 | |
| SCHEMBL24911011 | 0.79 | GBA1 (0.38) | GBA1EIF2AK4 | |
| SCHEMBL29323149 | 0.79 | GBA1 (0.38) | GBA1EIF2AK4 | |
| SCHEMBL22098703 | 0.77 | GBA1 (0.35) | GBA1 | |
| SCHEMBL13849313 | 0.77 | GBA1 (0.35) | GBA1 | |
| SCHEMBL30778470 | 0.76 | ATM (0.33) | ATM | |
| SCHEMBL21125084 | 0.74 | ATM (0.33) | ATM | |
| SCHEMBL16418013 | 0.74 | GBA1 (0.40) | GBA1 | |
| SCHEMBL16418011 | 0.74 | GBA1 (0.40) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224601-B1 | Compounds that inhibits MCL-1 protein | AMGEN INC. (US) | 2022-01-18 | — | — | US | disclosed |
| US-10300075-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2019-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10300075-B2 | Compounds that inhibit MCL-1 protein | MCL1, BCL9, BCL2L1 | GBA1 2878/4885EIF2AK4 1604/4885ATM 1729/4885 |
| US-11224601-B1 | Compounds that inhibits MCL-1 protein | MCL1, BCL9, BCL2L1 | GBA1 2797/4885EIF2AK4 1603/4885ATM 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.