Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13849313 | 1.00 | GBA1 (0.35) | GBA1DRD3SIGMAR1ALDH1A1 | |
| SCHEMBL19958962 | 0.85 | DRD3 (0.31) | DRD3 | |
| SCHEMBL27027460 | 0.85 | DRD3 (0.31) | DRD3 | |
| SCHEMBL3345331 | 0.79 | AGL (0.32) | GBA1 | |
| SCHEMBL22360701 | 0.78 | GBA1 (0.39) | GBA1DRD3SIGMAR1 | |
| SCHEMBL29341763 | 0.78 | GBA1 (0.39) | GBA1DRD3SIGMAR1 | |
| SCHEMBL23205043 | 0.77 | KCNJ1 (0.39) | GBA1DRD3SIGMAR1ALDH1A1 | |
| SCHEMBL21039435 | 0.77 | GBA1 (0.34) | GBA1 | |
| SCHEMBL25608578 | 0.77 | KCNJ1 (0.39) | GBA1DRD3SIGMAR1ALDH1A1 | |
| SCHEMBL12942344 | 0.76 | SIGMAR1 (0.36) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129832-B2 | Biheteroaryl compounds and uses thereof | GENENTECH, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200188397-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11129832-B2 | Biheteroaryl compounds and uses thereof | BCHE, SNCA, HAX1 | GBA1 26/4885DRD3 1056/4885SIGMAR1 1145/4885 |
| US-20200188397-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | BCHE, SNCA, HAX1 | GBA1 26/4885DRD3 1056/4885SIGMAR1 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.