Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17818766 | 0.91 | P2RX7 (1.00) | P2RX7IL1B | |
| SCHEMBL17834123 | 0.90 | P2RX7 (1.00) | P2RX7IL1B | |
| SCHEMBL17818785 | 0.90 | P2RX7 (1.00) | P2RX7IL1B | |
| SCHEMBL17818908 | 0.90 | P2RX7 (1.00) | P2RX7IL1B | |
| SCHEMBL17846570 | 0.90 | P2RX7 (0.80) | P2RX7IL1B | |
| SCHEMBL1018984 | 0.89 | P2RX7 (0.68) | P2RX7IL1B | |
| SCHEMBL17818930 | 0.89 | P2RX7 (1.00) | P2RX7IL1B | |
| SCHEMBL17818771 | 0.88 | P2RX7 (1.00) | P2RX7IL1B | |
| SCHEMBL17818826 | 0.88 | P2RX7 (1.00) | P2RX7IL1B | |
| SCHEMBL1019676 | 0.88 | P2RX7 (0.70) | P2RX7IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676433-B2 | Indole derivatives and their use in neurodegenerative diseases | MERCK PATENT GMBH (DE) | 2020-06-09 | — | — | US | disclosed |
| US-20190161447-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | MERCK PATENT GMBH (DE) | 2019-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190161447-A1 | NOVEL INDOLE DERIVATIVES AND THEIR USE IN NEURODEGENERATIVE DISEASES | P2RX3, P2RX7, P2RX2 | P2RX7 2/4885IL1B 668/4885 |
| US-10676433-B2 | Indole derivatives and their use in neurodegenerative diseases | P2RX3, ADORA2A, P2RX7 | P2RX7 3/4885IL1B 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.