Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | MYLK | Q15746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.40 |
| ▸ | GMNN | O75496 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92545 | 0.98 | KDM4E (0.56) | KDM4EKMT2ACYP3A4CYP2D6MYLK | |
| Hydrochloric Acid SCHEMBL189869 | 0.96 | KDM4E (0.54) | KDM4EKMT2ACYP3A4CYP2D6MYLK | |
| SCHEMBL8742086 | 0.91 | KDM4E (0.50) | KDM4EKMT2ACYP2D6MEN1TP53 | |
| Piperazine SCHEMBL28080505 | 0.91 | KDM4E (0.50) | KDM4EKMT2ACYP2D6MEN1TP53 | |
| Piperidine SCHEMBL28145582 | 0.89 | KDM4E (0.56) | KDM4EKMT2ACYP3A4CYP2D6MYLK | |
| SCHEMBL5013 | 0.89 | KDM4E (0.52) | KDM4EKMT2ACYP2D6MEN1TP53 | |
| SCHEMBL477197 | 0.89 | KDM4E (0.52) | KDM4EKMT2ACYP2D6MEN1TP53 | |
| Hydrochloric Acid SCHEMBL311054 | 0.86 | KDM4E (0.50) | KDM4EKMT2ACYP2D6MEN1TP53 | |
| Potassium SCHEMBL30601760 | 0.86 | KDM4E (0.50) | KDM4EKMT2ACYP2D6MEN1TP53 | |
| SCHEMBL24199230 | 0.84 | KDM4E (0.42) | KDM4EKMT2ACYP3A4CYP2D6MYLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224601-B1 | Compounds that inhibits MCL-1 protein | AMGEN INC. (US) | 2022-01-18 | — | — | US | disclosed |
| US-10300075-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2019-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10300075-B2 | Compounds that inhibit MCL-1 protein | MCL1, BCL9, BCL2L1 | KDM4E 1931/4885KMT2A 1644/4885CYP3A4 4129/4885 |
| US-11224601-B1 | Compounds that inhibits MCL-1 protein | MCL1, BCL9, BCL2L1 | KDM4E 1903/4885KMT2A 1649/4885CYP3A4 4103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.