Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742086 | 1.00 | KDM4E (0.50) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| SCHEMBL5013 | 0.97 | KDM4E (0.52) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| SCHEMBL477197 | 0.97 | KDM4E (0.52) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| Potassium SCHEMBL30601760 | 0.95 | KDM4E (0.50) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| Hydrochloric Acid SCHEMBL311054 | 0.95 | KDM4E (0.50) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| SCHEMBL21040872 | 0.91 | KDM4E (0.54) | KDM4EMAPTALDH1A1KMT2ALMNA | |
| Methylene Chloride SCHEMBL16447276 | 0.88 | KDM4E (0.45) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| Piperidine SCHEMBL28145582 | 0.88 | KDM4E (0.56) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| SCHEMBL92545 | 0.88 | KDM4E (0.56) | KDM4EMAPTALDH1A1NEK2KMT2A | |
| Hydrochloric Acid SCHEMBL189869 | 0.86 | KDM4E (0.54) | KDM4EMAPTALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641886-A | bicyclic BET bromodomain inhibitors and uses thereof | 康威基内有限公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-105814022-B | Condensed bicyclic heteroaromatic derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-105189515-B | Furopyridine class as bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-07-03 | — | — | CN | disclosed |
| CN-105814046-B | Imidazopyridine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-105814045-B | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-104470924-B | Imidazopyrazines derivant as TNF active regulator | UCB生物制药私人有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105814045-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814046-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-1922175-A | As 5-HT4Indazole-carboxamide compounds as receptor agonists | THERAVANCE INC (US) | 2007-02-28 | — | — | CN | disclosed |