SCHEMBL21042882

SCHEMBL21042882

O=C(c1ccnc(-c2nc3ccccc3[nH]2)c1)N1CCN(C(=O)c2ccnc(-c3nc4ccccc4[nH]3)c2)CC1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LANCL2 Q9NS86 1/20 0.62
▸ ATR Q13535 2/20 0.55
▸ HPGD P15428 3/20 0.52
▸ METAP2 P50579 2/20 0.52
▸ NPC1 O15118 2/20 0.52
▸ RAB9A P51151 2/20 0.52
▸ SMN1; SMN2 Q16637 2/20 0.52
▸ LMNA P02545 1/20 0.52
▸ PKM P14618 1/20 0.52
▸ MTOR P42345 1/20 0.52
▸ METAP1 P53582 1/20 0.52
▸ HTR2B P41595 3/20 0.52
▸ SPR P35270 3/20 0.51
▸ MEN1 O00255 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ HRH4 Q9H3N8 1/20 0.50
▸ MGLL Q99685 2/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ PDGFRB P09619 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17706589 0.84 KDM4E (0.70) LANCL2ATRHPGDNPC1RAB9A
SCHEMBL21043481 0.80 LANCL2 (0.66) LANCL2ATRHPGDNPC1RAB9A
SCHEMBL20762507 0.80 NPC1 (0.63) HPGDMETAP2NPC1RAB9ASMN1; SMN2
SCHEMBL21705044 0.80 LANCL2 (0.79) LANCL2ATRHPGDNPC1RAB9A
Omilancor SCHEMBL17706588 0.77 LANCL2 (1.00) LANCL2ATRHPGDMETAP2NPC1
Omilancor SCHEMBL29349469 0.77 LANCL2 (1.00) LANCL2ATRHPGDMETAP2NPC1
SCHEMBL25310542 0.76 LANCL2 (0.76) LANCL2ATRHPGDNPC1RAB9A
SCHEMBL12833993 0.76 MEN1 (0.66) LANCL2ATRHPGDSMN1; SMN2MTOR
SCHEMBL2952771 0.76 NPC1 (0.64) HPGDMETAP2NPC1RAB9ASMN1; SMN2
SCHEMBL30988885 0.76 NPC1 (0.64) HPGDMETAP2NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11197891-B2 Therapies with lanthionine C-like protein 2 ligands and cells prepared therewith LANDOS BIOPHARMA, INC. (US) 2021-12-14 — — US disclosed
US-20190160100-A1 THERAPIES WITH LANTHIONINE C-LIKE PROTEIN 2 LIGANDS AND CELLS PREPARED THEREWITH LANDOS BIOPHARMA, INC. (US) 2019-05-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190160100-A1 THERAPIES WITH LANTHIONINE C-LIKE PROTEIN 2 LIGANDS AND CELLS PREPARED THEREWITH LCP2, LANCL2, CALCB LANCL2 2/4885ATR 4863/4885HPGD 3981/4885
US-11197891-B2 Therapies with lanthionine C-like protein 2 ligands and cells prepared therewith LCP2, LANCL2, CALCB LANCL2 2/4885ATR 4863/4885HPGD 3981/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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