CALCB — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Trifluoroacetic Acid (SCHEMBL20564845)	0.83	19/20
SCHEMBL20563369	0.80	19/20
SCHEMBL20563869	0.79	19/20
SCHEMBL20564449	0.77	19/20
SCHEMBL22014005	0.77	19/20
SCHEMBL20563328	0.76	19/20
SCHEMBL22013984	0.76	19/20
SCHEMBL22013985	0.76	19/20
SCHEMBL22014045	0.76	19/20
SCHEMBL22014193	0.76	19/20
SCHEMBL22014164	0.75	19/20
SCHEMBL22014176	0.75	19/20
SCHEMBL22014281	0.75	19/20
SCHEMBL22014304	0.75	19/20
SCHEMBL22014481	0.75	19/20
SCHEMBL20564738	0.74	19/20
SCHEMBL20564417	0.74	19/20
SCHEMBL20564740	0.74	19/20
SCHEMBL20564741	0.74	19/20
SCHEMBL22014032	0.73	19/20

Clinical trials — most relevant to CALCB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hypersensitivity to CGRP as a Predictive Biomarker of Migraine Prevention With Erenumab	PHASE4	UNKNOWN
Decoding Pain Sensitivity in Migraine With Multimodal Brainstem-based Neurosignature	PHASE4	UNKNOWN
A Trial of Eptinezumab in Participants With Migraine and Insufficient Response to Anti-CGRP Medications	PHASE4	ACTIVE_NOT_RECRUITING
Functional Yogurt Powder Effect on Bone Health Biomarkers	PHASE3	COMPLETED
Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache	PHASE3	RECRUITING
PTHrP(1-36) IV Dose Escalation Study	PHASE1	WITHDRAWN
Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients	nan	COMPLETED
Procalcitonin Increase Identifies Critically Ill Patients at High Risk of Mortality	nan	COMPLETED
Clinical Characteristics and Pathophysiology of Post-Traumatic Headache	nan	COMPLETED
CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Effectiveness of Immersive Virtual Reality on Biomarkers and Clinical and Clinimetric Variables in Patients With Persistent Shoulder Pain	nan	COMPLETED
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
Stimulation-evoked Calcitonin Gene-Related Peptide (CGRP) as Biomarker of Migraine	nan	UNKNOWN
Calcitonin for Treating X-linked Hypophosphatemia	nan	COMPLETED
Calciotropic Effects After HCG Stimulation Test	nan	COMPLETED
Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide	nan	RECRUITING
Assessing Bone Calcium Content in Children With Kidney Disease Treated With Two Different Medicines	nan	UNKNOWN
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents	nan	RECRUITING
Comparison of Treximet & Imitrex as They Affect the Levels of Inflammatory Markers When the Patient is Actively Having a Migraine Headache	nan	COMPLETED
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.	nan	RECRUITING
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
The Role of Amylin in Bone Metabolism	nan	UNKNOWN
Calcitonin in Needle Wash Using Electrochemiluminescence Method For Diagnosis Of Medullary Thyroid Carcinoma.	nan	COMPLETED
CGRP-induced Migraine Attacks in Patients Who Have Tried Anti-CGRP Monoclonal Antibody Treatment	nan	UNKNOWN
A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis	nan	COMPLETED
Human Electrophysiological Model to Quantify the CGRP-related Axon Reflex of Trigeminal Afferents	nan	UNKNOWN
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)	nan	COMPLETED
Effect of Osteopathic Intervention on Migraine	nan	NOT_YET_RECRUITING
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CALCB binder may also engage these)

Protein	Name	Similarity
CALCA	Calcitonin gene-related peptide 1	1.000	landscape →
Q9N0T3	—	1.000	Q9N0T3 →
P01256	—	0.999	P01256 →
Q9MYV1	—	0.995	Q9MYV1 →
P10286	—	0.989	P10286 →
Q99JA0	—	0.988	Q99JA0 →
P10093	—	0.981	P10093 →
Q9N0T2	—	0.980	Q9N0T2 →
Q9QXK8	—	0.978	Q9QXK8 →
Q99MP3	—	0.977	Q99MP3 →
Q75V94	—	0.975	Q75V94 →
Q75V93	—	0.972	Q75V93 →
Q766Y7	—	0.970	Q766Y7 →
P48645	—	0.970	P48645 →
Q862B1	—	0.969	Q862B1 →
B3IWF7	—	0.969	B3IWF7 →
Q805D3	—	0.969	Q805D3 →
P12968	—	0.968	P12968 →
Q75V95	—	0.968	Q75V95 →
Q9Z0L6	—	0.967	Q9Z0L6 →
Q766Y6	—	0.967	Q766Y6 →
P17716	—	0.966	P17716 →
P04089	—	0.965	P04089 →
P12760	—	0.965	P12760 →
P12967	—	0.964	P12967 →
P01263	—	0.964	P01263 →
O09163	—	0.964	O09163 →
P81564	—	0.963	P81564 →
P53366	—	0.963	P53366 →
B3IWF8	—	0.963	B3IWF8 →