Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22001176 | 0.88 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL21043119 | 0.87 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL21042783 | 0.87 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL22001178 | 0.84 | POLB (0.39) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL22001377 | 0.82 | CHRM1 (0.58) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL22001746 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL21043462 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL8758318 | 0.79 | ALDH1A1 (0.76) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL21042583 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL21043130 | 0.79 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1HTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |