Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21043463 | 0.89 | MET (0.40) | ALDH1A1SMN1; SMN2HTTCHRM1MET | |
| SCHEMBL21042783 | 0.83 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HTTCHRM1MAPT | |
| SCHEMBL22001176 | 0.82 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTCHRM1MAPT | |
| SCHEMBL28467279 | 0.81 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2HTTSERPINE1MAPT | |
| SCHEMBL21043133 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2HTTCHRM1MAPT | |
| SCHEMBL28525408 | 0.78 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTSERPINE1MAPT | |
| SCHEMBL21043462 | 0.77 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTCHRM1MAPT | |
| SCHEMBL21043119 | 0.76 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HTTCHRM1MAPT | |
| SCHEMBL22001377 | 0.76 | CHRM1 (0.58) | ALDH1A1SMN1; SMN2HTTCHRM1MAPT | |
| SCHEMBL21043130 | 0.75 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |