Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21043477 | 0.89 | RAF1 (0.41) | PDE2ACHRM1EPHX2RAF1SERPINE1 | |
| SCHEMBL16593267 | 0.83 | CHRM1 (0.60) | CHRM1 | |
| SCHEMBL22001758 | 0.83 | CHRM1 (0.60) | CHRM1 | |
| SCHEMBL16593263 | 0.73 | CHRM1 (0.59) | CHRM1 | |
| SCHEMBL22001288 | 0.73 | CHRM1 (0.59) | CHRM1 | |
| SCHEMBL16593424 | 0.71 | CHRM1 (0.74) | CHRM1 | |
| SCHEMBL21043053 | 0.71 | CHRM1 (0.43) | CHRM1KDM4E | |
| SCHEMBL22001756 | 0.70 | PDPK1 (0.39) | CHRM1KLKB1 | |
| SCHEMBL16593234 | 0.69 | CHRM1 (0.74) | CHRM1 | |
| SCHEMBL16593229 | 0.69 | CHRM1 (0.74) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |