Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL3295023 | 1.00 | KDM4E (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Phosphoric Acid SCHEMBL9787198 | 1.00 | — | — | |
| Phosphoric Acid SCHEMBL28262328 | 0.95 | KDM4E (0.40) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Phosphoric Acid SCHEMBL15462414 | 0.95 | — | — | |
| Phosphoric Acid SCHEMBL27963740 | 0.95 | KDM4E (0.40) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Phosphoric Acid SCHEMBL29005800 | 0.91 | CA2 (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Phosphoric Acid SCHEMBL28379315 | 0.82 | CA2 (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Phosphoric Acid SCHEMBL7533290 | 0.82 | — | — | |
| Phosphoric Acid SCHEMBL4648159 | 0.82 | CA2 (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Phosphoric Acid SCHEMBL11382517 | 0.82 | CA2 (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158593-B2 | GPR17 modulators, method of screening and uses thereof | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2012-04-17 | — | — | US | disclosed |
| US-7807653-B2 | Nucleotide mimics and their prodrugs | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2010-10-05 | — | — | US | disclosed |
| US-20090156521-A1 | Gpr17 modulators,method of screening and uses thereof | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2009-06-18 | — | — | US | disclosed |
| EP-1807701-A2 | GPR17 MODULATORS, METHOD OF SCREENING AND USES THEREOF | UNIVERSITA'DEGLI STUDI DI MILANO (IT) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006045476-A2 | GPR17 MODULATORS, METHOD OF SCREENING AND USES THEREOF | UNIVERSITA'DEGLI STUDI DI MILANO (IT) | 2006-05-04 | — | — | WO | disclosed |