Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.67 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | POLB | P06746 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22692837 | 0.93 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21045380 | 0.90 | MAPT (0.68) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL22692834 | 0.83 | ALDH1A1 (0.68) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21045545 | 0.82 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL22404679 | 0.82 | ALDH1A1 (0.63) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21045548 | 0.82 | ALDH1A1 (0.72) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21045544 | 0.82 | ALDH1A1 (0.74) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21045253 | 0.81 | ALDH1A1 (0.62) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL21045560 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL11920013 | 0.80 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169138-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | ALDH1A1 4127/4885HPGD 1662/4885HSD17B10 1404/4885 |
| US-11760733-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | ALDH1A1 4127/4885HPGD 1662/4885HSD17B10 1404/4885 |
| US-20200281899-A1 | SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF | MFN2, FIS1, RHOT2 | ALDH1A1 4127/4885HPGD 1662/4885HSD17B10 1404/4885 |
| US-10844023-B2 | Small molecule regulators of mitochondrial fusion and methods of use thereof | MFN2, FIS1, RHOT2 | ALDH1A1 4127/4885HPGD 1662/4885HSD17B10 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.