Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103796 | 0.83 | CENPE (0.62) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL2104572 | 0.81 | CENPE (0.62) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL2104566 | 0.80 | CENPE (0.61) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL2617141 | 0.77 | CENPE (0.86) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL4435289 | 0.77 | HDAC1 (0.67) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL2105954 | 0.77 | CENPE (0.61) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL4720085 | 0.75 | CENPE (0.54) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL2101183 | 0.75 | CENPE (0.59) | CENPEHDAC1HDAC8HDAC6RORC | |
| SCHEMBL17660211 | 0.72 | MAPT (0.65) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2104733 | 0.72 | CENPE (0.56) | CENPEHDAC1HDAC8HDAC6RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163919-B2 | Imidazopyridinyl benzamide mitotic kinesin inhibitors | CYTOKINETICS, INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |