Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2617141 | 0.85 | CENPE (0.86) | CENPEHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL2103796 | 0.85 | CENPE (0.62) | CENPEHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL2105954 | 0.84 | CENPE (0.61) | CENPEHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL2104566 | 0.83 | CENPE (0.61) | CENPEHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL2101183 | 0.82 | CENPE (0.59) | CENPEHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL2104568 | 0.81 | CENPE (0.53) | CENPEHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL4720085 | 0.80 | CENPE (0.54) | CENPEHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL2617148 | 0.79 | CENPE (0.81) | CENPEMEN1KMT2ATOP2ARORC | |
| SCHEMBL2104968 | 0.78 | CENPE (0.58) | CENPEMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4767530 | 0.78 | CENPE (0.58) | CENPEMEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163919-B2 | Imidazopyridinyl benzamide mitotic kinesin inhibitors | CYTOKINETICS, INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |